The Harris Slide Test: A Microflocculation Test for Syphilis with Cardiolipin Antigen

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The Harris Slide Test: A Microflocculation Test for Syphilis with Cardiolipin Antigen.

The antigens in common use for the serological diagnosis of syphilis, such as the complement fixation tests and the various flocculation tests, are alcoholic extracts of ox heart usually sensitized with cholesterol. If, however, cholesterol is added to the crude alcoholic extract, false positive reactions are not uncommon. On this account it has become customary to purify the alcoholic extracts...

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The VDRL tube flocculation test; a microflocculation test for syphilis using cardiolipin-lecithin-cholesterol antigen.

In an earlier paper in this Journal (Vogelsang, 1947), a new microflocculation test for syphilis described by Harris, Rosenberg, and Riedel (1946) was compared with the Wassermann reaction, the Kahn standard test, and the Meinicke clarification test in 5,556 sera. The test was found to be very useful in the diagnosis of syphilis, having a satisfactory sensitivity and a good specificity. Harris ...

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The cardiolipin-lecithin test for syphilis.

as the antigen for a simplified precipitation test for syphilis. Cardiolipin is the lipid which, in combination with lecithin, gives the alcoholic extract of beef heart its antigenic properties. It is a complex phosphatidic acid with a molecular weight of 2195 and iodine number 120-125. It requires lecithin and cholesterol for antigenicity. It has not yet been synthesized. The cardiolipin-lecit...

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ژورنال

عنوان ژورنال: Sexually Transmitted Infections

سال: 1947

ISSN: 1368-4973

DOI: 10.1136/sti.23.3.109